Journal
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
Volume 6, Issue 20, Pages 4018-4025Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.5b01890
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Funding
- NSF [DMR-1408811]
- Scientific User Facilities Division of the DOE Office of Basic Energy Sciences (BES) [DE-AC05 00OR2275]
- Scientific User Facilities Division, Office of Basic Energy Sciences, DOE
- UT-Battelle, LLC [DE-AC0500OR22725]
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Elastin is a structural protein and biomaterial that provides elasticity and resilience to a range of tissues. This work provides insights into the elastic properties of elastin and its peculiar inverse temperature transition (ITT). These features are dependent on hydration of elastin and are driven by a similar mechanism of hydrophobic collapse to an entropically favorable state. Using neutron scattering, we quantify the changes in the geometry of molecular motions above and below the transition temperature, showing a reduction in the displacement of water-induced motions upon hydrophobic collapse at the ITT. We also measured the collective vibrations of elastin gels as a function of elongation, revealing no changes in the spectral features associated with local rigidity and secondary structure, in agreement with the entropic origin of elasticity.
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