Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 101, Issue -, Pages 51-58Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2013.11.028
Keywords
beta-N-methylamino-L-alanine; BMAA; Metabolism; Cyanobacteria; Neurotoxin; Mussels
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Funding
- Water Research Commission of South Africa
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The cyanobacterial neurotoxin, beta-N-methylamino-L-alanine (BMAA) has been suggested as a causative agent for certain neurodegenerative diseases. This cyanotoxin bioaccumulates in an array of aquatic organisms, in which it occurs as both a free amino acid and in a protein-associated form. This study was intended to investigate the environmental fate of BMAA by examining the metabolism of isotopically labeled BMAA in four freshwater mussel species. All species showed substantial uptake of BMAA from the culture media. Data showed no significant evidence for BMAA catabolism in any of the animals but did suggest metabolism via the reversible covalent modification of BMAA in freshwater mussels, a process that appears to be variable in different species. (C) 2014 Published by Elsevier Inc.
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