Journal
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
Volume 6, Issue 11, Pages 2022-2026Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.5b00524
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Funding
- [NSF-MCB-0947767]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0947767] Funding Source: National Science Foundation
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Lambda Cro repressor is one of the best studied dimeric transcription factors. However, there has still been an unsettled debate for decades about whether it is a two-state dimer or three-state dimer. We provide a new mechanism model that can reconcile these seemingly conflicting (mutually exclusive) experimental results. From simulations with all-atom structure-based model, we observe that the dimerization process of Lambda Cro repressor starts from one folded monomer with one unfolded monomer. Intrasubunit folding and intersubunit binding are partially coupled, in a fly casting manner.
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