Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 105, Issue -, Pages 97-102Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2014.04.012
Keywords
Cytochrome P450 1A; Heavy metals; Metallothionein; Mosquitofish; Vitellogenin
Categories
Funding
- National Natural Science Foundation of China [U1133005, 41201522, 41273119]
- Guangdong Provincial Natural Science Foundation [S2012040006898]
- China Postdoctoral Science Foundation [20100480786]
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The aim of this study was to evaluate the effects of three metals (Zn, Cd and Pb) on hepatic metallothionein (MT), cytochrome P450 1A (CYP1A) and vitellogenin (Vtg) mRNA expression in the liver of adult female mosquitofish (Gambusia affinis) after 1, 3 or 8 d. Both concentration-response and time-course effects of hepatic MT, CYP1A and Vtg at the transcription level were determined by quantitative real-time PCR. The results from this study showed that Zn, Cd and Pb could significantly induced MT. CYP1A and Vtg mRNA expression levels in mosquitofish. In general, this study demonstrated that heavy metals modulate MT, CYP1A and Vtg mRNA expression levels in a metal-, concentration- or time-dependent manner. (C) 2014 Published by Elsevier Inc.
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