Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 74, Issue 5, Pages 1156-1163Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2011.02.015
Keywords
Cadmium toxicity; Synechogobius hasta; Antioxidant responses; Histology; Ultrastructure; Hepatic intermediary metabolism; Fatty liver syndrome
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Funding
- National Natural Science Foundation of China [30800850]
- New Century Excellent Talents in University, Ministry of Education, China [NCET-08-0782]
- Key Laboratory of Mariculture Ecology and Quality Control, Ministry of Agriculture [2007-4]
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The present study was conducted to determine antioxidant responses, hepatic intermediary metabolism, histology and ultrastructure in Synechogobius hasta after a 15-days of waterborne cadmium (Cd) exposure at the concentrations of 0 (control), 0.10, 0.17 and 0.29 mg CO (corresponding to 0, 12.6%, 21.5% and 36.7% of 96 h LC50), respectively. Growth performance and survival declined, but hepatosomatic index (HSI) increased with increasing waterborne Cd levels (P<0.05). Waterborne Cd exposure also significantly increased lipid contents in whole body and liver (P<0.05), and Cd accumulation in whole body, muscle and vertebrae. Waterborne Cd exposure changed hepatic enzymatic activities involved in intermediary metabolism, induced antioxidant responses and increased lipid peroxidation level in the gill, liver and spleen. Waterborne Cd exposure also caused considerable histological alterations of gill, liver and spleen, led ultrastructures damage of liver and spleen of fish, and induced fatty liver for this fish species. (C) 2011 Elsevier Inc. All rights reserved.
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