Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 73, Issue 7, Pages 1620-1628Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2010.07.009
Keywords
Mutagenicity; Genotoxicity; Tannery effluent; Ames Salmonella test; XAD; GC-MS; Dichloromethane; Solvent
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Funding
- Council of Scientific and Industrial Research, Government of India [24(0271)104/EMR-II]
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The tannery effluents at Kanpur (India) have been in use for irrigation since last many years, polluting soil directly while ground water and food crops indirectly. Gas chromatography-mass spectrometric analysis of the test samples revealed the presence of organic compounds including diisooctyl phthalate, phenyl N-methylcarbamate, dibutyl phthalate, bis 2-methoxyethyl phthalate, and higher alkanes. Tannery effluent extracts were prepared using XAD-4/8 resins, dichloromethane, chloroform, and hexane and tested with Ames Salmonella test and DNA repair-defective Escherichia coif K-12 mutants. In the presence of)(AD-concentrated tannery effluent, TA98 found to be the most sensitive strain in terms of mutagenic index followed by TA97a whereas in terms of mutagenic potential TA102 was most responsive. The extracts were also found genotoxic as determined in terms of survival of E. coli K-12 mutants, suggesting the presence of DNA damaging compounds in the tannery effluents. In the light of results, precautious use of tannery effluents for irrigation is suggested. (C) 2010 Elsevier Inc. All rights reserved.
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