Journal
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
Volume 72, Issue 2, Pages 552-556Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ecoenv.2007.11.002
Keywords
Ionic liquid; Rana nigromaculata; Developmental toxicity; Early embryonic development
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Funding
- National Natural Science Foundation of China [20273019, 20573034]
- Henan Innovation Project for University Prominent Research Talents (HAIPURT) [2006KYCX021]
- Ministry of Education of China [[2006] 331]
- Henan Normal University [521838]
- Key Subject of Zoology in Henan Province, China
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Toxic effects of 1-methyl-3-octylimidazolium bromide ([C8mim]Br) on the early embryonic development of the frog Rana nigromaculata were evaluated. Frog embryos in different developmental stages (early cleavage, early gastrula, or neural plate) were exposed to 0, 45, 63, or 88.2 mg/L of the ionic liquid [C(8)mim]Br for 96 h. The 96-h median lethal concentration values at the early cleavage, early gastrula, and neural plate stages of development were 85.1, 43.4, and 42.4 mg/L, respectively. In embryos exposed to [C(8)mim]Br, the duration of embryo dechorionation was prolonged in the early cleavage and neural plate, but not the early gastrula, stages of development compared with control embryos. Embryos in the neural plate developmental stage were found to have the highest mortality rate following [C(8)mim]Br exposure. These results suggest that [C8mim]Br has toxic effects on the early embryonic development of the frog. (C) 2007 Elsevier Inc. All rights reserved.
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