Journal
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
Volume 6, Issue 13, Pages 2616-2621Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.5b01014
Keywords
-
Categories
Funding
- James Madison University
- U.S. DOE
- NNSA [DEAC52-06NA25396]
- U.S. DOE Basic Energy Sciences Office
- Center for Integrated Nanotechnologies, a U.S. DOE Office of Basic Energy Sciences
- ERC [DM 321031]
- Knut and Alice Wallenberg (KAW) foundation
Ask authors/readers for more resources
In this study, we examine the mechanism of nanopore-based DNA sequencing using a voltage bias across a graphene nanoribbon. Using density function theory and a nonequilibrium Green's function approach, we determine the transmission spectra and current profile for adenine, guanine, cytosine, thymine, and uracil as a function of bias voltage in an energy minimized configuration. Utilizing the transmission current, we provide a general methodology for the development of a three nanopore graphene-based device that can be used to distinguish between the various nucleobases for DNA/RNA sequencing. From our analysis, we deduce that it is possible to use different transverse currents across a multinanopore device to differentiate between nucleobases using various voltages of 0.5, 1.3, and 1.6 V. Overall, our goal is to improve nanopore design to further DNA/RNA nucleobase sequencing and biomolecule identification techniques.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available