Journal
ECOTOXICOLOGY
Volume 22, Issue 8, Pages 1241-1254Publisher
SPRINGER
DOI: 10.1007/s10646-013-1112-7
Keywords
Avermectin; Pigeon; Serum; Brain tissue; Oxidative stress
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Funding
- National Natural Science Foundation of China [30972226]
- Research Fund for the Doctoral Program of Higher Education of China [20102325110014]
- Foundation for University Key Teacher by the Heilongjiang Province [1155G11]
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Avermectins (AVMs) are the active components of some insecticidal and nematicidal products used in agriculture and veterinary medicine for the prevention of parasitic diseases. Residues of AVM drugs or their metabolites in livestock feces have toxic effects on non-target aquatic and terrestrial organisms. In this study, oxidative stress responses and pathological changes on pigeon brain tissues and serum after subchronic exposure to AVM for 30, 60 and 90 days were investigated. The decrease in antioxidant enzyme (superoxide dismutase, SOD and glutathione peroxidase, GSH-Px) activities and increase in methane dicarboxylic aldehyde content in a dose-time-dependent manner in the brain and serum of pigeon were observed. The protein carbonyl content, an indicator of protein oxidation, and DNA-protein crosslink coefficient were significantly augmented with dose-time-dependent properties. The microscopic structures of the cerebrum, cerebellum and optic lobe altered obviously, the severity of which increased with the concentration of AVM and exposure time. The results imply that AVM could induce oxidative damage to the brain tissue and serum of pigeon. The information presented in this study is helpful to understand the mechanism of AVM-induced oxidative stress in birds.
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