Journal
ECOTOXICOLOGY
Volume 20, Issue 5, Pages 993-999Publisher
SPRINGER
DOI: 10.1007/s10646-011-0645-x
Keywords
Decabromodiphenyl ether; BDE-209; Oxidative stress; Hydroxyl radical (center dot OH); Earthworm
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Funding
- National Basic Research Program of China (973 program) [2009CB421604]
- China-EU International S&T Cooperation Program [0911]
- Pollution Control and Resource Reuse (Nanjing University, PR China)
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Antioxidant responses induced by decabromodiphenyl ether (BDE-209) in the earthworms (Eisenia fetida) were studied after 7 days of exposure. Electron paramagnetic resonance (EPR) spectra indicated that hydroxyl radicals (aEuro cent OH) in earthworms were significantly induced by 0.01-10 mg/kg of BDE-209. Malondialdehyde (MDA) and protein carbonyl (PCO) were stimulated at 0.5-10 mg/kg and 1-10 mg/kg, respectively. The reduced glutathione (GSH) was inhibited at 1-10 mg/kg while oxidized glutathione (GSSG) accumulated at 0.5-10 mg/kg. The GSH/GSSG ratio decreased at 0.5-10 mg/kg, and superoxide dismutase (SOD) and glutathione-S-transferase (GST) activities were induced at 0.1-1 and 0.5 mg/kg, respectively and both decreased at 10 mg/kg. Catalase (CAT) activities increased at 1-10 mg/kg. The results showed that severe oxidative stress occurred in E. fetida, and may play an important role in inducing the toxicity of BDE-209 on earthworms.
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