Journal
JOURNAL OF PHYSICAL CHEMISTRY C
Volume 119, Issue 50, Pages 28148-28154Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcc.5b07796
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Magnetic hyperthermia is a promising tool as an adjuvant therapy for multimodal cancer treatment. However, the heating efficiency of magnetic nanoparticles in biological conditions remains poorly understood, especially regarding the influence of their dispersion state. In this work, dynamic light scattering (DLS) and hyperthermia experiments were coupled to highlight the role of aggregation of iron oxide nanopartides on their heating properties. Bare, poly(acrylit acid) coated, and poly(acrylic acid-co-maleic acid) coated nanopartides were studied. Interparticular interactions were investigated by varying both ionic strength arid pH. Our results show that the specific loss power (six) of nanopartides in small loose aggregates is similar to that of well-dispersed nanopartides while the formation of large and dense aggregates observed by DLS leads to a significant decrease of the SLP. However, for intermediate aggregation states, DLS experiments alone do not allow fully grasping the links between heating properties and aggregation. Small angle X-ray scattering experiments (SAXS) were then performed to get further information about aggregate structure. It appears that the compactness of aggregates plays a crucial role, with closer nanopartides leading to a more important decrease of heating efficiency.
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