Journal
ECOLOGICAL MODELLING
Volume 221, Issue 9, Pages 1325-1328Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ecolmodel.2010.01.015
Keywords
Mechanistic effect models; Survival; Ecotoxicology; Individual tolerance; Hazard models; Individual based model; Heterogeneity; Pulsed exposure
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Funding
- Swiss National Science Foundation [200021-119795]
- Bundesamt fur Umwelt [09.033.PJ, I362-1602, 09.0012.PJ]
- Swiss National Science Foundation (SNF) [200021-119795] Funding Source: Swiss National Science Foundation (SNF)
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Toxicokinetic-toxicodynamic (TKTD) models simulate the time-course of toxicant concentration in the organism and toxicity at the level of the organism. A link between TKTD models that simulate survival and individual based models for populations (IBMs) is proposed which allows TKTD parameters to vary between individuals. The TKTD-IBM predicts different survival in response to toxicants when TKTD parameters vary amongst individuals compared to the survival predicted with fixed TKTD parameters. The model with fixed parameters represents the concept of stochastic death whereas the model with variable parameters behaves, at least partly, according to the individual tolerance distribution concept. The whole set of TKTD parameters of an individual can be interpreted as constituting individual tolerance. (C) 2010 Elsevier B.V. All rights reserved.
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