Journal
JOURNAL OF PHYSICAL CHEMISTRY B
Volume 119, Issue 4, Pages 1416-1424Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jp511492q
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Funding
- EPSRC [EP/G009546/1]
- Wellcome Trust
- Wolfson Foundation [092506, 098335]
- Oxford Instruments
- University of York
- Engineering and Physical Sciences Research Council [EP/G009546/1, EP/H029575/1, EP/F022530/1, GR/S23605/01] Funding Source: researchfish
- EPSRC [EP/H029575/1, EP/G009546/1, EP/F022530/1] Funding Source: UKRI
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We report on a strategy for using SABRE (signal amplification by reversible exchange) for polarizing H-1 and C-13 nuclei of weakly interacting lingans which possess biologically relevant and nonaromatic motifs. We first demonstrate this via the polarization of acetonitrile, using Ir(IMes) (COD) CI as the catalyst precursor, and confirm that the route to hyperpolarization transfer is via the J - coupling network. We extend this work to the polarization of propionitrile, benzylnitrile, benzonitirle, and trans-3-hexenedinitrile in order to assess its generality. In the H-1 NMR spectrum, the signal for acetonitrile is enhanced 8-fold over its thermal counterpart when [Ir(H)(2) (IMes) (MeCN)(3)](+) is the catalyst. Upon addition of pyridine or pyridine-d(5), the active catalyst changes to [Ir(H)(2) (IMes) (py)(2) (MeCN)](+) and the resulting acetonitirle H-1 signal enhancement increases to 20- and 60-fold, respectively. In C-13 NMR studies, polarization transfers to optimally to the quaternary C-13 nucleus of MeCN while the methyl C-13 is hardly polarzied. Transfer to C-13 is shown to occur first via the H-1-H-1 coupling betwen the hydrides and the methyl protons and then via either the (2)J or (1)J couplings to the resepctive Cs-13, of which the (2)J route is more efficient. These experimental results are rationalized through a theoretical treatment which shows excellent agreement with experiment. In the case of MeCN, longitudinal two-spin orders between pairs of H-1 nuclei in the three-spin methylgroup are created. Two-spin order states, between the H-1 and C-13 nuclei, are also created, and their existence is confirmed for (MeCN)-C-13 in both the H-1 and C-13 NMR spectra using the Only Parahydrogen Spectroscopy protocol.
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