Journal
EARLY INTERVENTION IN PSYCHIATRY
Volume 10, Issue 1, Pages 54-62Publisher
WILEY
DOI: 10.1111/eip.12141
Keywords
antipsychotic; developing country; psychotic disorder; schizophrenia
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Funding
- Department of Science and Technology of South Africa
- Medical Research Council of South Africa
- Lundbeck International
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AimTo assess the feasibility and effectiveness of depot antipsychotic (flupenthixol decanoate) combined with an assertive monitoring programme (AMP) in first-episode schizophrenia. MethodsThis was a prospective, non-comparative, longitudinal study conducted over 12 months assessing patient acceptance, adherence, outcome in domains of psychopathology, functionality and quality of life, and tolerability. ResultsOf 207 participants, 149 (72%) completed 12 months of treatment. Acceptance of and adherence to depot was good. Treatment response was achieved by 170 (82%) participants and remission by 124 (60%). Thirty-three (19%) responders relapsed and 10 (5%) participants met a priori criteria for treatment resistance. Treatment was generally well tolerated. ConclusionsCombination of depot antipsychotic with an AMP may be an effective and safe intervention in early phases of schizophrenia, and may be particularly suitable for resource-constrained settings.
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