Journal
EARLY HUMAN DEVELOPMENT
Volume 90, Issue 7, Pages 325-328Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.earlhumdev.2014.04.003
Keywords
Meconium-stained amniotic fluid; Pathophysiology; Hypoxia; Foetal ripening
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Introduction: Despite the many efforts to study the (patho)physiology of meconium release before delivery, it still remains an indistinct subject. Some studies have reported a relationship between hypoxia and MSAF, whilst others have not. The most common association found however, is between MSAF and the term of gestation. Methods: MEDLINE, EMBASE and the Cochrane library were electronically searched. Papers about the (patho) physiology of meconium-stained amniotic fluid in English were included. Papers about management strategies were excluded (see elsewhere this issue). Results: Different theories have been proposed including acute or chronic hypoxia, physiologic foetal ripening and peripartum infection. Conclusion: We suggest that meconium-stained amniotic fluid should be regarded as a symptom rather than a syndrome becoming more prevalent with increasing term and which might be associated with higher levels of infection or asphyxia. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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