Journal
EARLY HUMAN DEVELOPMENT
Volume 88, Issue 8, Pages 595-601Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.earlhumdev.2012.01.003
Keywords
Gangliosides; Complex lipids; Cognitive; Human milk; Infant formula; Infant
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Funding
- Fonterra Brands Ltd (AME)
- Fonterra Co-operative Ltd, Auckland, New Zealand
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Background: Human breastmilk contains gangliosides which may play an important role in infant neurodevelopment. Aim: A pilot study was conducted to assess the impact of infant formula supplemented with gangliosides from complex milk lipid on cognitive functions of normal healthy infants. Study design: The study was a double-blind, randomized, controlled, parallel group clinical trial in which infants received the treatment or control product from 2 to 8 weeks of age until 24 weeks of age. The control group (n = 30) received standard infant formula and the treatment group (n = 29) received the same formula supplemented with complex milk lipid to increase the ganglioside content to approximately 11 to 12 mu g/ml. A reference group (n = 32) consisted of normal healthy exclusively breast-fed infants. Outcome measures: Cognitive development using the Griffith Scales and serum gangliosides was measured before (2-8 weeks of age) and after intervention (24 weeks of age). Results: Ganglioside supplementation using complex milk lipids significantly increased ganglioside serum levels (control group vs treatment group, P = 0.002) and resulted in increased scores for Hand and Eye coordination IQ (P < 0.006), Performance IQ (P < 0.001) and General IQ (P = 0.041). Cognitive development scores and serum ganglioside levels for the treatment group did not differ from the reference group. Conclusions: Supplementation of infant formula with complex milk lipid to enhance ganglioside content appears to have beneficial effects on cognitive development in healthy infants aged 0-6 months, which may be related to increased serum ganglioside levels. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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