Journal
EARLY HUMAN DEVELOPMENT
Volume 88, Issue -, Pages S35-S40Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.earlhumdev.2011.12.026
Keywords
IUGR; MRI; Organ volume
Categories
Ask authors/readers for more resources
Objectives: We used magnetic resonance imaging (MRI) to perform volumetry of foetuses with and without growth restriction, and identify deviations in organ growth. Study design: 20 growth restricted and 19 normal foetuses were scanned once during pregnancy at gestational age 20.53-36.57 weeks. MRI scans were performed on a 1.5 T system using ssFSE sequences. Manual segmentation of whole body, brain, heart, lung, liver, thymus and kidney volume was performed. Data on the severity of foetal growth restriction and pregnancy outcome was collected. Results: There was a significant reduction in foetal whole body volume and volume of all internal organs except the brain in growth restricted foetuses. A brain:liver ratio above 3.0 was associated with a 3.3 fold increase in risk of perinatal mortality (95% CI = 1.68-6.47). Conclusion: MRI provides an accurate assessment of feotal organ growth. It may have a role to play in monitoring disease severity and the effect of future interventions. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available