Journal
EARLY HUMAN DEVELOPMENT
Volume 84, Issue 1, Pages 51-57Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.earlhumdev.2007.03.005
Keywords
omega-3 and-6 fatty acids; long chain polyunsaturated fatty acids (LC-PUFAs); brainstem auditory evoked potentials (BAEPs); cluster analysis
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Objective: To identify biological and socioeconomic factors associated with the neurological development of Mexican infants born at term, as measured by brainstem auditory-evoked potentials (BAEPs). Subjects and methods: We conducted a cohort study among 76 women with low risk pregnancies recruited in their third trimester of pregnancy and followed their infants until 12 months of age. BAEP tests were conducted on the infants before 3 months of age during physiologic steep, using 100 msec bipolar clicks. Maternal dietary intake was evaluated by food frequency questionnaire. Two BAEP groups (short latency, long latency) were identified by cluster analysis. The association between BAEP group and maternal PUFAs was estimated using logistic regression models adjusted for socioeconomic and biological factors. Results: Short latency BAEPs were associated with a maternal diet rich in arachidonic acid (OR=3.63, 95% CI 1.23-10.67) after adjusting for age (in days) sex, head circumference and gestational age but was not significantly associated to a maternal diet rich in docosahexaenoic acid (DHA). Conclusions: Our results suggest the importance of arachidonic acid intake during pregnancy for short latency BAEPs and adequate fetal. myelination. (c) 2007 Published by Elsevier Ireland Ltd.
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