Journal
DYES AND PIGMENTS
Volume 99, Issue 2, Pages 465-471Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2013.05.010
Keywords
Fluorescent probes; Ratiometric; pH; Coumarin; Cellular imaging; Quinoline
Funding
- NSFC [20972044, 21172063]
- NCET [08-0175]
- Doctoral Fund of Chinese Ministry of Education [20100161110008]
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It is highly desirable to develop ratiometric pH probes with a well-resolved emission spectrum for biological imaging applications. In this work the design, synthesis, photophysical properties and cellular imaging studies of a new linked coumarin quinoline probe is described. The major features of the novel probe include two well-resolved (>100 nm) emission peaks, strong fluorescence under acidic conditions, a pKa of 4.69, low cytotoxicity and good cell membrane permeability; features which render the probe useful for monitoring pH variations from neutral to acidic conditions in living cells. (C) 2013 Elsevier Ltd. All rights reserved.
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