Journal
DYES AND PIGMENTS
Volume 99, Issue 2, Pages 308-315Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2013.05.008
Keywords
Biothiols; Fluorescent probes; Two-photon imaging; Arylsulfonyl azides; Arylsulfonamide; Mitochondrial thiols
Funding
- EPB Center through the National Research Foundation, Korea [R11-2008-052-01001]
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Two-photon probes for biothiols are developed based on arylsulfonyl azides for the first time. Thus, 6-(dimethylamino)naphthalene-2-sulfonyi azide and its triphenylphosphonium derivative undergo a fast reduction with turn-on fluorescence change by typical biothiols such as hydrogen sulfide, glutathione, cysteine, and homocysteine to produce the corresponding sulfonamides that is two-photon excitable. The cationic probe enables the selective imaging of the biothiols in mitochondria by two-photon fluorescence microscopy. (C) 2013 Elsevier Ltd. All rights reserved.
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