Journal
DYES AND PIGMENTS
Volume 88, Issue 3, Pages 326-332Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2010.08.002
Keywords
Niclosamide derivative; 4 Morpholin 1 8 naphthalimide; Schistosoma Japonicum cercariae; Fluorescence imaging; Self diffusion; Fluorescent labelling
Funding
- National Natural Science Foundation of China (NSFC) [50727803, 50968002]
- National Key Technologies RD Program [2009BAI78B01]
- Shanghai Leading Academic Discipline Project [B108]
Ask authors/readers for more resources
Two novel niclosamide derivatives were synthesized by adding polyethylene glycol groups of differing lengths to a niclosamide core The modified niclosamide derivatives were characterized using H-1 NMR and HRMS spectra Anti-cercarial bioactivity results showed that the niclosamide derivative constructed to float on the surface of the water was able to kill cercariae when the number of hydrophilic groups was >3 A fluorescent niclosamide derivative containing naphthalimide was further synthesized to observe the interaction between the cercaricide and Schistosoma japonicum cercariae Confocal fluorescence microscopy revealed that the fluorescent niclosamide derivative could easily penetrate into the cercarial body beyond the circulatory system leading to the rapid death of cercariae (C). 2010 Elsevier Ltd All rights reserved
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available