Journal
DRUG TESTING AND ANALYSIS
Volume 3, Issue 11-12, Pages 836-850Publisher
WILEY
DOI: 10.1002/dta.372
Keywords
sports drug testing; LC-MS; MS; dilute-and-shoot; high-throughput screening; plasma volume expanders; DEHP glucuronides
Funding
- Federal Ministry of the Interior of the Federal Republic of Germany
- World Anti-Doping Agency
- Antidoping Switzerland
- Manfred Donike Institut fur Dopinganalytik e.V.
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A new multi-target approach based on liquid chromatography electrospray ionization tandem mass spectrometry (LC-(ESI)-MS/MS) is presented to screen for various classes of prohibited substances using direct injection of urine specimens. With a highly sensitive new generation hybrid mass spectrometer classic groups of drugs for example, diuretics, beta2-agonists stimulants and narcotics are detectable at concentration levels far below the required limits.
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