Journal
DRUG TESTING AND ANALYSIS
Volume 2, Issue 9-10, Pages 496-502Publisher
WILEY
DOI: 10.1002/dta.185
Keywords
naphyrone; legal highs; NRG-1; nuclear magnetic resonance spectroscopy; mass spectrometry; forensic; clinical
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Naphyrone (naphthylpyrovalerone, O-2482) has been recently advertised for purchase on a number of websites. This compound has been viewed as a so-called 'legal high' and was classified as a controlled drug under the UK Misuse of Drugs Act 1971 in mid-July 2010. So far, naphyrone is commonly equated with 1-naphthalen-2-yl-2-pyrrolidin-1-yl-pentan-1-one (beta-naphyrone) but analytical characterization of two naphyrone samples revealed the existence of a novel isomer consistent with 1-naphthalen-1-yl-2-pyrrolidin-1-yl-pentan-1-one (alpha-naphyrone). Analyses of both alpha- and beta-naphyrone were carried out using gas chromatography ion trap (EI/CI) mass spectrometry and 1D/2D nuclear magnetic resonance spectroscopy. This provides the first report of alpha-naphyrone in the scientific literature and the ability to differentiate it from the beta-isomer should be of interest to forensic and clinical communities. Copyright (C) 2010 John Wiley & Sons, Ltd.
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