Journal
DRUG RESISTANCE UPDATES
Volume 13, Issue 3, Pages 57-66Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.drup.2010.02.001
Keywords
microRNA; Drug resistance; Cancer therapy; Isoflavone; DIM; I3C; Curcumin; EGCC
Categories
Funding
- National Cancer Institute, NIH [5R01CA083695, 2R01CA108535, 5R01CA131151, 3R01CA131151-02S109, 1R01CA132794]
- University of Texas MD Anderson Cancer Center [5P20-CA101936, 3P20CA101936-05S109]
- NATIONAL CANCER INSTITUTE [R01CA131151, R01CA083695, R01CA108535, P20CA101936, R01CA132794] Funding Source: NIH RePORTER
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Recently, microRNAs (miRNAs) have received increasing attention in the field of cancer research. miRNAs play important roles in many normal biological processes: however, the aberrant miRNA expression and its correlation with the development and progression of cancers is an emerging field. Therefore, miRNAs could be used as biomarkers for diagnosis of cancer and prediction of prognosis. Importantly, some miRNAs could regulate the formation of cancer stern cells and the acquisition of epithelial-mesenchymal transition, which are critically associated with drug resistance. Moreover, some miRNAs could target genes related to drug sensitivity, resulting in the altered sensitivity of cancer cells to anti-cancer drugs. Emerging evidences have also shown that knock-down or re-expression of specific miRNAs by synthetic anti-sense oligonucleotides or pre-miRNAs could induce drug sensitivity, leading to increased inhibition of cancer cell growth, invasion, and metastasis. More importantly, recent studies have shown that natural agents including isoflavone, 3,3'-diindolylmethane, and (-)-epigallocatechin-3-gallate altered miRNA expression profiles, leading to an increased sensitivity of cancer cells to conventional therapeutics. These emerging results suggest that specific targeting of miRNAs by different approaches could open new avenues for cancer treatment through overcoming drug resistance and thereby improve the outcome of cancer therapy. (C) 2010 Elsevier Ltd. All rights reserved.
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