Journal
DRUG METABOLISM REVIEWS
Volume 46, Issue 2, Pages 142-154Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/03602532.2013.876429
Keywords
Diagnosis; imaging techniques; in vitro and in vivo; magnetic resonance; selectivity; superparamagnetic nanomaterials
Categories
Funding
- EPSCoR
- Office Of The Director [1003970] Funding Source: National Science Foundation
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Improvements in diagnostic measures for biomedical applications have been investigated in various studies for better interpretations of biological abnormalities and several medical conditions. The use of imaging techniques, such as magnetic resonance imaging (MRI), is widespread and becoming a standard procedure for such specialized applications. A major avenue being studied in MRI is the use of magnetic nanoparticles (NPs) as contrast agents (CAs). Among various approaches, current research also incorporates use of superparamagnetic iron oxide NPs and manganese-ased NPs with biocompatible coatings for improved stability and reduced biodegradation when exposed to a biological environment. In this review, recent advances with these types of magnetic NPs and their potential use as CAs in MRI are reported, as well as new insights into the selectivity and cellular transport mechanism that occurs following injection.
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