Journal
DRUG METABOLISM REVIEWS
Volume 44, Issue 4, Pages 287-301Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/03602532.2012.725414
Keywords
Apoptosis; cancer; resistance; metallothioneins; zinc; NF-kappa B; protein p53; prognostic factor; tumor marker
Categories
Funding
- CYTORES [GA CR P301/10/0356, CEITEC CZ.1.05/1.1.00/02.0068, IGA TP 6/2012]
Ask authors/readers for more resources
Metallothioneins (MTs) are involved in protection against oxidative stress (OS) and toxic metals and they participate in zinc metabolism and its homeostasis. Disturbing of zinc homeostasis can lead to formation of reactive oxygen species, which can result in OS causing alterations in immunity, aging, and civilization diseases, but also in cancer development. It is not surprising that altered zinc metabolism and expression of MTs are of great interest in the case of studying of oncogenesis and cancer prognosis. The role of MTs and zinc in cancer development is tightly connected, and the structure and function of MTs are strongly dependent on Zn2+ redox state and its binding to proteins. Antiapoptic effects of MTs and their interactions with proteins nuclear factor kappa B, protein kinase C, esophageal cancer-related gene, and p53 as well as the role of MTs in their proliferation, immunomodulation, enzyme activation, and interaction with nitric oxide are reviewed. Utilization of MTs in cancer diagnosis and therapy is summarized and their importance for chemoresistance is also mentioned.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available