Journal
DRUG METABOLISM REVIEWS
Volume 43, Issue 2, Pages 281-291Publisher
INFORMA HEALTHCARE
DOI: 10.3109/03602532.2011.556122
Keywords
2-hydroxychromene-2-carboxylic acid isomerase; adiponectin; gene expression; glutathione transferase kappa; lipid metabolism; mitochondria; peroxisome; polymorphisms; protein-protein interaction
Categories
Funding
- Institut National de la Sante et de la recherche Medicale
- Association pour la Recherche sur le Cancer
Ask authors/readers for more resources
Glutathione transferase (GST) kappa, also named mitochondrial GST, is a very ancient protein family with orthologs in bacteria and eukaryotes. Both the structure and the subcellular localization of GSTK1-1, in mitochondria and peroxisomes, make this enzyme distinct from cytosolic GSTs. Rodent and human GSTK1 exhibit activity towards a number of model GST substrates and, in Caenorhabditis elegans, this enzyme may be involved in energy and lipid metabolism, two functions related to mitochondria and peroxisomes. Interestingly, GST kappa is also a key regulator of adiponectin biosynthesis and multimerization suggesting that it might function as a chaperone to facilitate correct folding and assembly of proteins. Since adiponectin expression has been correlated with insulin resistance, obesity and diabetes, GSTK1 expression level which is negatively correlated with obesity in mice and human adipose tissues may be an important factor in these metabolic disorders. Furthermore, a polymorphism in the hGSTK1 promoter has been associated with insulin secretion and fat deposition.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available