Journal
DRUG METABOLISM REVIEWS
Volume 43, Issue 1, Pages 1-26Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/03602532.2010.515222
Keywords
Heme synthesis; heme degradation; P450 inactivation; P450 transcription; P450 translation; P450 repair; P450 disposal
Categories
Funding
- Royal Society of Edinburgh
- NIH [DK26506, GM44037]
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Heme is vital to our aerobic universe. Heme cellular content is finely tuned through an exquisite control of synthesis and degradation. Heme deficiency is deleterious to cells, whereas excess heme is toxic. Most of the cellular heme serves as the prosthetic moiety of functionally diverse hemoproteins, including cytochromes P450 (P450s). In the liver, P450s are its major consumers, with >50% of hepatic heme committed to their synthesis. Prosthetic heme is the sine qua non of P450 catalytic biotransformation of both endo- and xenobiotics. This well-recognized functional role notwithstanding, heme also regulates P450 protein synthesis, assembly, repair, and disposal. These less well-appreciated aspects are reviewed herein.
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