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J Bart et al.
EUROPEAN JOURNAL OF CANCER (2004)
Small hepatocytes in culture develop polarized transporter expression and differentiation
MAS Pfändler et al.
JOURNAL OF CELL SCIENCE (2004)
Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access
K Sasaki et al.
MOLECULAR PHARMACOLOGY (2004)
Analysis of ATP-binding cassette transporter expression in drug-selected cell lines by a microarray dedicated to multidrug resistance
JP Annereau et al.
MOLECULAR PHARMACOLOGY (2004)
Expression and immunolocalization of the multidrug resistance proteins, Mrp1-Mrp6 (ABCC1-ABCC6), in human brain
AT Nies et al.
NEUROSCIENCE (2004)
Contribution of multidrug resistance protein 2 (MRP2/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter
PHE Smeets et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2004)
Differential multidrug resistance-associated protein 1 through 6 isoform expression and function in human intestinal epithelial Caco-2 cells
HM Prime-Chapman et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver
J Shoda et al.
HEPATOLOGY (2004)
Radixin: cytoskeletal adopter and signaling protein
KP Hoeflich et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
Cyclosporin A, but not tacrolimus, inhibits the biliary excretion of mycophenolic acid glucuronide possibly mediated by multidrug resistance-associated protein 2 in rats
M Kobayashi et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2004)
Enteric excretion of baicalein, a flavone of scutellariae radix, via glucuronidation in rat: Involvement of multidrug resistance-associated protein 2
T Akao et al.
PHARMACEUTICAL RESEARCH (2004)
Raft and cytoskeleton associations of an ABC transporter:: P-glycoprotein
Z Bacso et al.
CYTOMETRY PART A (2004)
P-glycoprotein: from genomics to mechanism
SV Ambudkar et al.
ONCOGENE (2003)
The MRP family of drug efflux pumps
GD Kruh et al.
ONCOGENE (2003)
Biliary excretion of flavopiridol and its glucuronides in the isolated perfused rat liver:: role of multidrug resistance protein 2 (Mrp2)
W Jäger et al.
LIFE SCIENCES (2003)
Metabolism and disposition of gemfibrozil in Wistar and multidrug resistance-associated protein 2-deficient TR- rats
MS Kim et al.
XENOBIOTICA (2003)
Involvement of multidrug resistance associated protein 1 (Mrp1) in the efflux transport of 17β estradiol-D-17β-glucuronide (E217βG) across the blood-brain barrier
D Sugiyama et al.
PHARMACEUTICAL RESEARCH (2003)
Hepatobiliary elimination of bile acid-modified oligodeoxynucleotides in Wistar and TR- rats:: evidence for mrp2 as carrier for oligodeoxynucleotides
K Lischka et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Biliary excretion of phenolphthalein sulfate in rats
H Tanaka et al.
PHARMACOLOGY (2003)
Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane
M Rius et al.
HEPATOLOGY (2003)
Estradiol-17β-D-glucuronide induces endocytic internalization of Bsep in rats
FA Crocenzi et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)
Phenobarbital alters hepatic Mrp2 function by direct and indirect interactions
NJ Patel et al.
MOLECULAR PHARMACOLOGY (2003)
Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions
A Bodó et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Evidence for two interacting ligand binding sites in human multidrug resistance protein 2 (ATP binding cassette C2)
N Zelcer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Identification of domains participating in the substrate specificity and subcellular localization of the multidrug resistance proteins MRP1 and MRP2
T Konno et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Hepatobiliary excretion of acetaminophen glutathione conjugate and its derivatives in transport-deficient (TR-) hyperbilirubinemic rats
C Chen et al.
DRUG METABOLISM AND DISPOSITION (2003)
Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets
U Beuers et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Effects of maturation on RNA transcription and protein expression of four MRP genes in human placenta and in BeWo cells
L Pascolo et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
C-terminal phosphorylation of MRP2 modulates its interaction with PDZ proteins
T Hegedüs et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Pharmacokinetics of 5 (and 6)-carboxy-2′,7′-dichlorofluorescein and its diacetate promoiety in the liver
MJ Zamek-Gliszczynski et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2003)
Antidepressant induced cholestasis: hepatocellular redistribution of multidrug resistant protein (MRP2)
P Milkiewicz et al.
GUT (2003)
Targeted disruption of the PDZK1 gene by homologous recombination
O Kocher et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2)
V Keitel et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)
Impact of mrp2 on the biliary excretion and intestinal absorption of furosemide, probenecid, and methotrexate using Eisai hyperbilirubinemic rats
CP Chen et al.
PHARMACEUTICAL RESEARCH (2003)
Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells
H Lou et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)
Impaired renal secretion of substrates for the multidrug resistance protein 2 in mutant transport-deficient (TR-) rats
R Masereeuw et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2003)
Stereoselective hepatic disposition of a diastereomeric pair of alpha(v)beta(3) antagonists in rat
T Prueksaritanont et al.
XENOBIOTICA (2003)
Development of a novel in vitro model to predict hepatic clearance using fresh, cryopreserved, and sandwich-cultured hepatocytes
YY Lau et al.
DRUG METABOLISM AND DISPOSITION (2002)
Multidrug resistance protein 2 (MRP2) transports HIV protease inhibitors, and transport can be enhanced by other drugs
MT Huisman et al.
AIDS (2002)
Trafficking and functional defects by mutations of the ATP-binding domains in MRP2 in patients with Dubin-Johnson syndrome
K Hashimoto et al.
HEPATOLOGY (2002)
Identification of a mechanism by which the methylmercury antidotes N-acetylcysteine and dimercaptopropanesulfonate enhance urinary metal excretion:: Transport by the renal organic anion transporter-1
AS Koh et al.
MOLECULAR PHARMACOLOGY (2002)
Hepatobiliary excretion of dipyrrinone sulfonates in Mrp2-deficient (TR-) rats
AF McDonagh et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2002)
Mechanisms of impaired biliary excretion of acetaminophen glucuronide after acute phenobarbital treatment or phenobarbital pretreatment
H Xiong et al.
DRUG METABOLISM AND DISPOSITION (2002)
Role of the N-terminal transmembrane region of the multidrug resistance protein MRP2 in routing to the apical membrane in MDCKII cells
SBM Fernández et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Multidrug resistance-associated protein2 (MRP2) plays an important role in the biliary excretion of glutathione conjugates of 4-hydroxynonenal
B Ji et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
Regulation of expression of the multidrug resistance associated protein 2 (MRP2) and its role in drug disposition
PM Gerk et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)
Expression of multidrug resistance-associated protein 2 (MRP2) in normal human tissues and carcinomas using tissue microarrays
GE Sandusky et al.
HISTOPATHOLOGY (2002)
Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes
S Kikuchi et al.
NATURE GENETICS (2002)
Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?
FX Tang et al.
PHARMACEUTICAL RESEARCH (2002)
Reconstitution of transport-active multidrug resistance protein 2 (MRP2; ABCC2) in proteoliposomes
W Hagmann et al.
BIOLOGICAL CHEMISTRY (2002)
Increased expression of multidrug resistance-associated proteins in bladder cancer during clinical course and drug resistance to doxorubicin
Y Tada et al.
INTERNATIONAL JOURNAL OF CANCER (2002)
Increased renal expression of bilirubin glucuronide transporters in a rat model of obstructive jaundice
Y Tanaka et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2002)
Structural requirements for the apical sorting of human multidrug resistance protein 2 (ABCC2)
AT Nies et al.
EUROPEAN JOURNAL OF BIOCHEMISTRY (2002)
Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2)
M Sasaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Inhibition of Mrp2-and Ycf1p-mediated transport by reducing agents: evidence for GSH transport on rat Mrp2
JF Rebbeor et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2002)
Involvement of multidrug resistance-associated protein 2 in intestinal secretion of grepafloxacin in rats
K Naruhashi et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2002)
P-glycoprotein-actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid origin
F Luciani et al.
BLOOD (2002)
High multidrug resistance protein activity in acute myeloid leukaemias is associated with poor response to chemotherapy and reduced patient survival
B Laupeze et al.
BRITISH JOURNAL OF HAEMATOLOGY (2002)
Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma
AT Nies et al.
INTERNATIONAL JOURNAL OF CANCER (2001)
Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome
R Mor-Cohen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The expression of P-glycoprotein and multidrug resistance proteins 1 and 2 (MRP1 and MRP2) in human malignant mesothelioma
Y Soini et al.
ANNALS OF ONCOLOGY (2001)
Beneficial effects of silymarin on estrogen-induced cholestasis in the rat:: A study in vivo and in isolated hepatocyte couplets
FA Crocenzi et al.
HEPATOLOGY (2001)
Sinusoidal efflux of taurocholate is enhanced in Mrp2-deficient rat liver
H Akita et al.
PHARMACEUTICAL RESEARCH (2001)
Transport of the β-O-glucuronide conjugate of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1) -: Requirement for glutathione or a non-sulfur-containing analog
EM Leslie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Identification of the apical membrane-targeting signal of the multidrug resistance-associated protein 2 (MRP2/cMOAT)
MJ Harris et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Physicochemical parameters responsible for the affinity of methotrexate analogs for rat canalicular multispecific organic anion transporter (cMOAT/MRP2)
YH Han et al.
PHARMACEUTICAL RESEARCH (2001)
Mrp2-deficiency in the rat impairs biliary and intestinal excretion and influences metabolism and disposition of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
CG Dietrich et al.
CARCINOGENESIS (2001)
Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump
H Akita et al.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2001)
Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases
G Zollner et al.
HEPATOLOGY (2001)
Characterization and inhibition by a wide range of xenobiotics of organic anion excretion by primary human hepatocytes
L Payen et al.
BIOCHEMICAL PHARMACOLOGY (2000)
Identification of basic residues involved in drug export function of human multidrug resistance-associated protein 2
S Ryu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome
V Keitel et al.
HEPATOLOGY (2000)
Glutathione S-transferase-π gene expression and platinum drug exposure in human lung cancer
T Oguri et al.
CANCER LETTERS (2000)
Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export
R Evers et al.
BRITISH JOURNAL OF CANCER (2000)
Expression and immunolocalization of multidrug resistance protein 2 in rabbit small intestine
RAMH Van Aubel et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2000)
Mrp2 is essential for estradiol-17β(β-D-glucuronide)-induced cholestasis in rats
LY Huang et al.
HEPATOLOGY (2000)
Biliary excretion of 17β-estradiol 17β-D-glucuronide is predominantly mediated by cMOAT/MRP2
A Morikawa et al.
PHARMACEUTICAL RESEARCH (2000)
ATP-dependent para-aminohippurate transport by apical multidrug resistance protein MRP2
I Leier et al.
KIDNEY INTERNATIONAL (2000)
Pharmacokinetic study of the hepatobiliary transport of indomethacin
H Kouzuki et al.
PHARMACEUTICAL RESEARCH (2000)
Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver
B Stieger et al.
GASTROENTEROLOGY (2000)
Hepatic secretion of conjugated drugs and endogenous substances
D Keppler et al.
SEMINARS IN LIVER DISEASE (2000)
Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver
CC Paulusma et al.
HEPATOLOGY (2000)
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