Journal
DRUG METABOLISM REVIEWS
Volume 40, Issue 4, Pages 539-551Publisher
INFORMA HEALTHCARE
DOI: 10.1080/03602530802413338
Keywords
Polymorphism; Variant; Drug; Tamoxifen; Warfarin; PharmGKB; Disease; Gene; Pharmacogenetics; Pharmacogenomics
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Funding
- NIH/NIGMS Pharmacogenetics Research Network (PGRN) and Database [U01GM61374]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [U01GM061374] Funding Source: NIH RePORTER
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The Pharmacogenetics and Pharmacogenomics Knowledge Base (PharmGKB: http://www.pharmgkb.org) is devoted to disseminating primary data and knowledge in pharmacogenetics and pharmacogenomics. We are annotating the genes that are most important for drug response and present this information in the form of Very Important Pharmacogene (VIP) summaries, pathway diagrams, and curated literature. The PharmGKB currently contains information on over 500 drugs, 500 diseases, and 700 genes with genotyped variants. New features focus on capturing the phenotypic consequences of individual genetic variants. These features link variant genotypes to phenotypes, increase the breadth of pharmacogenomics literature curated, and visualize single-nucleotide polymorphisms on a gene's three-dimensional protein structure.
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