Journal
DRUG METABOLISM AND PHARMACOKINETICS
Volume 25, Issue 2, Pages 122-133Publisher
JAP SOC STUDY XENOBIOTICS
DOI: 10.2133/dmpk.25.122
Keywords
drug-induced liver injury; drug-induced myopathy; human lymphocyte antigen; Stevens-Johnson syndrome; toxic epidermal necrolysis
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Severe adverse drug reactions (ADRs) are a major issue for drug therapy because they can cause serious disorders and be life-threatening Many severe ADRs appear to be idiosyncratic and unpredictable Genetic factors may underlie susceptibility to severe ADRs, and identification of predisposing genotypes may improve drug therapy by facilitating prescreening of carriers for specific genetic biomarkers In this review, we clarify the current status of ADRs in Japan from open ADR data sources Then, we introduce recent progress in the field of pharmacogenetic biomarkers for severe cutaneous ADRs, liver injury, and statin-induced myopathy Key challenges for discovery of predictable risk alleles for these severe ADRs are also discussed
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