Related references
Note: Only part of the references are listed.QT and TdP - QT: an unreliable predictor of proarrhythmia.
Luc M. Hondeghem
ACTA CARDIOLOGICA (2008)
Bioinformatics, multiscale modeling and the IUPS physiome project
Peter J. Hunter et al.
BRIEFINGS IN BIOINFORMATICS (2008)
In vitro models of proarrhythmia
C. L. Lawrence et al.
BRITISH JOURNAL OF PHARMACOLOGY (2008)
Use and abuse of QT and TRIaD in cardiac safety research: Importance of study design and conduct
Luc M. Hondeghem
EUROPEAN JOURNAL OF PHARMACOLOGY (2008)
Computational analysis of the effects of the hERG channel opener NS1643 in a human ventricular cell model
Torben Peitersen et al.
HEART RHYTHM (2008)
Validation testing in thorough QT/QTc clinical trials
Yi Tsong et al.
JOURNAL OF BIOPHARMACEUTICAL STATISTICS (2008)
Statistical issues of QT prolongation assessment based on linear concentration modeling
Yi Tsong et al.
JOURNAL OF BIOPHARMACEUTICAL STATISTICS (2008)
Commentary on the clinical relevance of concentration/QTc relationships for new drug candidates
Daniel Bloomfield et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2008)
Concentration-QT relationships play a key role in the evaluation of proarrhythmic risk during regulatory review
Christine E. Garnett et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2008)
Computational models of the heart and their use in assessing the actions of drugs
Denis Noble
JOURNAL OF PHARMACOLOGICAL SCIENCES (2008)
Modeling ventricular repolarization: Effects of transmural and apex-to-base heterogeneities in action potential durations
P. Colli-Franzone et al.
MATHEMATICAL BIOSCIENCES (2008)
Long-QT syndrome
Dan M. Roden
NEW ENGLAND JOURNAL OF MEDICINE (2008)
Preclinical Torsades-de-Pointes screens: Advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk
Gary A. Gintant
PHARMACOLOGY & THERAPEUTICS (2008)
Relevance of in vitro SCREENIT results for drug-induced QT interval prolongation in vivo: A database review and analysis
B. M. Dumotier et al.
PHARMACOLOGY & THERAPEUTICS (2008)
The hERG potassium channel and hERG screening for drug-induced torsades de pointes
Jules C. Hancox et al.
PHARMACOLOGY & THERAPEUTICS (2008)
The canine virtual ventricular wall: A platform for dissecting pharmacological effects on propagation and arrhythmogenesis
Alan P. Benson et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2008)
In silico risk assessment for drug-induction of cardiac arrhythmia
Shingo Suzuki et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2008)
A guide to modelling cardiac electrical activity in anatomically detailed ventricles
R. H. Clayton et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2008)
Selective block of IKs plays a significant role in MAP triangulation induced by IKr block in isolated rabbit heart
N.C. Guérard et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2008)
Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study
Martin Hinterseer et al.
EUROPEAN HEART JOURNAL (2008)
Eight (or more) kinds of alternans
Alan Garfinkel
JOURNAL OF ELECTROCARDIOLOGY (2007)
Analyses of dynamic Beat-to-Beat QT-TQ interval (ECG restitution) changes in humans under normal sinus rhythm and prior to an event of Torsades de Pointes during QT prolongation caused by Sotalol
Anthony A. Fossa et al.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (2007)
Drug-induced QT prolongation and proarrhythmia: an inevitable link?
Karnran Ahmad et al.
EUROPACE (2007)
The pinwheel experiment revisited: effects of cellular electrophysiological properties on vulnerability to cardiac reentry
Ming-Jim Yang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
Does Tpeak-Tend provide an index of transmural dispersion of repotarization?
Charles Antzelevitch et al.
HEART RHYTHM (2007)
Frequency-dependent effects of various IKr blockers on cardiac action potential duration in a human atrial model
Kenji Tsujimae et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2007)
Preclinical cardiovascular risk assessment in modern drug development
Brian D. Guth
TOXICOLOGICAL SCIENCES (2007)
From the Hodgkin-Huxley axon to the virtual heart
Denis Noble
JOURNAL OF PHYSIOLOGY-LONDON (2007)
Cardiac repolarization and the safety of new drugs defined by electrocardiography
J. Morganroth
CLINICAL PHARMACOLOGY & THERAPEUTICS (2007)
A comparison of monodomain and bidomain reaction-diffusion models for action potential propagation in the human heart
Mark Potse et al.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2006)
Precision of QT interval measurement by advanced electrocardiographic equipment
Katerina Hnatkova et al.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY (2006)
Effects of transmural electrical heterogeneities and electrotonic interactions on the dispersion of cardiac repolarization and action potential duration: A simulation study
P. Colli-Franzone et al.
MATHEMATICAL BIOSCIENCES (2006)
Assessing the proarrhythmic potential of drugs: Current status of models and surrogate parameters of torsades de pointes arrhythmias
Morten B. Thomsen et al.
PHARMACOLOGY & THERAPEUTICS (2006)
The virtual ventricular wall: A tool for exploring cardiac propagation and arrhythmogenesis
Arun V. Holden et al.
JOURNAL OF BIOLOGICAL PHYSICS (2006)
Vulnerable window for conduction block in a one-dimensional cable of cardiac cells, 1: Single extrasystoles
Zhilin Qu et al.
BIOPHYSICAL JOURNAL (2006)
Man versus machine: Is there an optimal method for QT measurements in thorough QT studies?
Borje Darpo et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2006)
From pulsus to Pulseless the saga of cardiac alternans
James N. Weiss et al.
CIRCULATION RESEARCH (2006)
Defibrillation of the heart: insights into mechanisms from modelling studies
N Trayanova
EXPERIMENTAL PHYSIOLOGY (2006)
Thorough QT/QTc not so thorough: Removes torsadogenic predictors from the T-wave, incriminates safe drugs, and misses profibrillatory drugs
LM Hondeghem
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2006)
Moving towards better predictors of drug-induced Torsade de Pointes - 2-3 November 2005, Crystal City, Virginia, USA
Icilio Cavero et al.
EXPERT OPINION ON DRUG SAFETY (2006)
Computational biology in the study of cardiac ion channels and cell electrophysiology
Yoram Rudy et al.
QUARTERLY REVIEWS OF BIOPHYSICS (2006)
QT interval measurement - Evaluation of automatic QTc measurement and new simple method to calculate and interpret corrected QT interval
B Charbit et al.
ANESTHESIOLOGY (2006)
The cardiac hERG/I-Kr potassium channel as pharmacological target: Structure, function, regulation, and clinical applications
D. Thomas et al.
CURRENT PHARMACEUTICAL DESIGN (2006)
Preclinical cardiac safety assessment of pharmaceutical compounds using an integrated systems-based computer model of the heart
D Bottino et al.
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2006)
The dynamics of cardiac fibrillation
JN Weiss et al.
CIRCULATION (2005)
Refining detection of drug-induced proarrhythmia: QT interval and TRIaD
RR Shah et al.
HEART RHYTHM (2005)
Verapamil prevents torsade de pointes by reduction of transmural dispersion of repolarization and suppression of early afterdepolarizations in an intact heart model of LQT3
P Milberg et al.
BASIC RESEARCH IN CARDIOLOGY (2005)
Assessment of the stability of the individual-based correction of QT interval for heart rate
JP Couderc et al.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (2005)
Pharmacokinetic-pharmacodynamic modeling in the data analysis and interpretation of drug-induced QT/QTc prolongation
V Piotrovsky
AAPS JOURNAL (2005)
The role of stochastic and modal gating of cardiac L-type Ca2+ channels on early after-depolarizations
AJ Tanskanen et al.
BIOPHYSICAL JOURNAL (2005)
Basic mechanisms of cardiac impulse propagation and associated arrhythmias
AG Kléber et al.
PHYSIOLOGICAL REVIEWS (2004)
Drug-induced Torsades de Pointes and implications for drug development
RR Fenichel et al.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2004)
Drug therapy: Drug-induced prolongation of the QT interval
DM Roden
NEW ENGLAND JOURNAL OF MEDICINE (2004)
Inhibition of hERG K+ currents by antimalarial drugs in stably transfected HEK293 cells
M Traebert et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Intracellular calcium cycling, early afterdepolarizations, and reentry in simulated long QT syndrome
R Huffaker et al.
HEART RHYTHM (2004)
Differences between study-specific and subject-specific heart rate corrections of the QT interval in investigations of drug induced QTc prolongation
M Malik et al.
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY (2004)
Errors and misconceptions in ECG measurement used for the detection of drug induced QT interval prolongation
M Malik
JOURNAL OF ELECTROCARDIOLOGY (2004)
Drug-induced QT interval prolongation: regulatory perspectives and drug development
RR Shah
ANNALS OF MEDICINE (2004)
Assessing predictors of drug-induced torsade de pointes
L Belardinelli et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2003)
The dominant T wave and its significance
A van Oosterom
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2003)
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
WS Redfern et al.
CARDIOVASCULAR RESEARCH (2003)
Integration from proteins to organs: the Physiome Project
PJ Hunter et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Detection of proarrhythmia in the female rabbit heart: Blinded validation
LM Hondeghem et al.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2003)
Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: Importance of triangulation, reverse use dependence, and instability
LM Hondeghem et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2003)
Novel approaches antiarrhythmic to identifying drugs
JN Weiss et al.
TRENDS IN CARDIOVASCULAR MEDICINE (2003)
Estimation of the QT/RR hysteresis lag
E Pueyo et al.
JOURNAL OF ELECTROCARDIOLOGY (2003)
Identification of sotalol-induced changes in repolarization with T wave area-based repolarization duration parameters
JP Couderc et al.
JOURNAL OF ELECTROCARDIOLOGY (2003)
Modelling the heart: insights, failures and progress
D Noble
BIOESSAYS (2002)
Troubleshooting problems with in vitro screening of drugs for QT interval prolongation using HERG K+ channels expressed in mammalian cell lines and Xenopus oocytes
HJ Witchel et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2002)
How antiarrhythmic drugs increase the rate of sudden cardiac death
CF Starmer
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS (2002)
Modelling cardiac repolarisation for the study of the T wave: effect of repolarisation sequence
D di Bernardo et al.
CHAOS SOLITONS & FRACTALS (2002)
Ionic current basis of electrocardiographic waveforms - A model study
K Gima et al.
CIRCULATION RESEARCH (2002)
Drug-induced prolongation of the QT interval: why the regulatory concern?
RR Shah
FUNDAMENTAL & CLINICAL PHARMACOLOGY (2002)
Relation between QT and RR intervals is highly individual among health subjects: implications for heart rate correction of the QT interval
M Malik et al.
HEART (2002)
The role of pharmacokinetics, drug interactions and pharmacogenetics in the acquired long QT syndrome
JL Bauman
EUROPEAN HEART JOURNAL SUPPLEMENTS (2001)
Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death
CE Clancy et al.
CARDIOVASCULAR RESEARCH (2001)
Problems of heart rate correction in assessment of drug-induced QT interval prolongation
M Malik
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY (2001)
Action potential and contractility changes in [Na+]i overloaded cardiac myocytes:: A simulation study
GM Faber et al.
BIOPHYSICAL JOURNAL (2000)
Medical physics - Explaining the T-wave shape in the ECG
D di Bernardo et al.
NATURE (2000)
Share Paper
