Journal
DRUG DISCOVERY TODAY
Volume 24, Issue 2, Pages 462-491Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2018.08.009
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Funding
- Culture Affairs and Mission Sector, Ministry of Higher Education, Government of Egypt
- NCI/NIH [R21CA179652]
- Wayne State University
- American Cancer Society (ACS-IRG) [449355]
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Cancer is the second highest cause of death worldwide. Several therapeutic approaches, such as conventional chemotherapy, antibodies and small molecule inhibitors and nanotherapeutics have been employed in battling cancer. Amongst them, nanotheranostics is an example of successful personalized medicine bearing dual role of early diagnosis and therapy to cancer patients. In this review, we have focused on various types of theranostic polymer and metal nanoparticles for their role in cancer therapy and imaging concerning their limitation, future application such as dendritic cell cancer vaccination, gene delivery, T-cell activation and immune modulation. Also, some of the recorded patent applications and clinical trials have been illustrated. The impact of the biological microenvironment on the biodistribution and accumulation of nanoparticles have been discussed.
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