Journal
DRUG DISCOVERY TODAY
Volume 19, Issue 4, Pages 413-424Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2013.12.003
Keywords
-
Categories
Funding
- MRC [MR/K019074/1] Funding Source: UKRI
- British Heart Foundation [PG/09/104/28136, PG/12/63/29824] Funding Source: researchfish
- Medical Research Council [MR/K019074/1] Funding Source: researchfish
- British Heart Foundation [PG/09/104/28136, PG/12/63/29824] Funding Source: Medline
- Medical Research Council [MR/K019074/1] Funding Source: Medline
Ask authors/readers for more resources
Potassium channels are key regulators of smooth muscle tone, with increases in activity resulting in hyperpolarisation of the cell membrane, which acts to oppose vasoconstriction. Several potassium channels exist within smooth muscle, but the K(v)7 family of voltage-gated potassium channels have been identified as being crucial mediators of this process in a variety of smooth muscle. Recently, K(v)7 channels have been shown to be involved in the pathogenesis of hypertension, as well as being implicated in other smooth muscle disorders, providing a new and inviting target for smooth muscle disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available