Journal
DRUG DISCOVERY TODAY
Volume 19, Issue 6, Pages 794-800Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2014.01.012
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Funding
- NIH [R21-A1R060480]
- Raymond and Beverly Sackler Center for Biomedical, Biological, Physical and Engineering Sciences
- State of Connecticut Stem Cell Research Foundation
- Presidential Faculty Fellowship Award from President William Clinton
- Presidential Award for Excellence in Science, Mathematics, and Engineering Mentorship from President Barack Obama
- Directorate For Engineering
- Emerging Frontiers & Multidisciplinary Activities [1332329] Funding Source: National Science Foundation
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Stimulation of bone regeneration using growth factors is a promising approach for musculoskeletal regenerative engineering. However, common limitations with protein growth factors, such as high manufacturing costs, protein instability, contamination issues, and unwanted immunogenic responses of the host reduce potential clinical applications. New strategies for bone regeneration that involve inexpensive and stable small molecules can obviate these problems and have a significant impact on the treatment of skeletal injury and diseases. Over the past decade, a large number of small molecules with the potential of regenerating skeletal tissue have been reported in the literature. Here, we review this literature, paying specific attention to the prospects for small molecule-based bone-regenerative engineering. We also review the preclinical study of small molecules associated with bone regeneration.
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