Journal
DRUG DISCOVERY TODAY
Volume 19, Issue 12, Pages 1913-1920Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2014.09.019
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Funding
- University Grant Commission (UGC), New Delhi, India [F7-57/2007/BSR]
- Indian Council of Medical Research (ICMR), New Delhi, India [45/03/2011/PHA-BMS]
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The concept of RNA interference (RNAi) is gaining popularity for the better management of various diseases, including HIV. Currently, the successful biomedical utilization of siRNA therapeutics is hampered, both in vivo and in vitro, mainly by the inherent inability of naked siRNA to cross the cell membrane. RNAi can potentially improve the weakness of current highly active antiretroviral therapy (HAART) by diminishing the chances of the appearance of antiHIV-resistant strains. Here, we discuss the nanocarrier-mediated delivery of siRNA delivery as well as highlighted the scope of siRNA-mediated gene-silencing technology for improved HIV treatment.
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