Journal
DRUG DISCOVERY TODAY
Volume 19, Issue 8, Pages 1172-1177Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2014.05.014
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Funding
- Medical Research Council [1095739] Funding Source: researchfish
- Rosetrees Trust [M380] Funding Source: researchfish
- Versus Arthritis [19654] Funding Source: researchfish
- MRC [MR/K013076/1] Funding Source: UKRI
- Arthritis Research UK [19654] Funding Source: Medline
- Medical Research Council [MR/K013076/1] Funding Source: Medline
- Versus Arthritis [19654] Funding Source: Medline
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Cartilage breakdown is the disabling outcome of rheumatic diseases, whether prevalently inflammatory such as rheumatoid arthritis or prevalently mechanical such as osteoarthritis (OA). Despite the differences between immune-mediated arthritides and OA, common mechanisms drive cartilage breakdown. Inflammation, chondrocyte phenotype and homeostatic mechanisms have recently been the focus of research and will be summarised in this review.
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