Journal
DRUG DISCOVERY TODAY
Volume 19, Issue 4, Pages 373-378Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2013.11.002
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Chronic inflammation has a key role in the pathogenesis of multiple diseases that represent major public health and financial concerns, including heart failure (HF), Alzheimer's disease (AD) and arthritis. Nuclear factor kappa beta (NF-kappa beta) is a central component of inflammation; owing to its upstream signaling position, it is considered an attractive target for new anti-inflammatory therapeutics. Hydroxytyrosol is an orally bioavailable polyphenol, obtained from olives, which inhibits NF-kappa beta activity and has elicited promising efficacy signals in several inflammatory diseases. Here, we further examine the role of NF-kappa beta in inflammation, provide an introduction to natural products and their anti-inflammatory effects and explore the potential of hydroxytyrosol as a new approach to combating the burden of chronic inflammatory diseases.
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