Journal
DRUG DISCOVERY TODAY
Volume 19, Issue 7, Pages 999-1002Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2014.03.009
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- Novo Nordisk Fonden [NNF13OC0003882] Funding Source: researchfish
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Regular physical exercise has undisputed health benefits in the prevention and the treatment of many diseases. Understanding the mechanisms that regulate adaptations to exercise training therefore has obvious clinical perspectives. Several lines of evidence suggest that the AMP-activated protein kinase (AMPK) has a central role as a master metabolic regulator in skeletal muscle. Exercise is a potent activator of AMPK, and AMPK signaling can play a key part in regulating protein turnover during and after exercise training.
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