Journal
DRUG DISCOVERY TODAY
Volume 18, Issue 19-20, Pages 922-935Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2013.05.016
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Funding
- EPSRC [EP/H028277/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [1069963] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/H028277/1] Funding Source: researchfish
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Bringing a new drug to market is costly in terms of capital and time investments, and any development issues encountered during late-stage clinical trials can often be the result of in vitro-in vivo extrapolations (IVIVE) not accurately reflecting clinical outcome. In the discipline of drug metabolism and pharmacokinetics (DMPK), current in vitro cellular methods do not provide the 3D structure and function of organs found in vivo; therefore, new dynamic methods need to be established to aid improvement of IVIVE. In this review, we highlight the importance of model progression into dynamic systems for use within drug development, focusing on devices developed currently in the areas of the liver and blood-brain barrier (BBB), and the potential to develop models for other organ systems, such as the kidney.
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