Journal
DRUG DISCOVERY TODAY
Volume 18, Issue 19-20, Pages 936-949Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2013.05.007
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Funding
- Research Centre, College of Pharmacy King Saud University
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In this review, we discuss the methodologies and platform technologies for enhancing the oral bioavailability of poorly soluble drugs. We also highlight the mechanisms of formulation technologies for improving desired physicochemical attributes of active substances. We focus on various commercial technologies, along with marketed products, and identify proprietary technologies protected by patents. We also discuss nonpropriety technologies, such as mesoporous silica, cyclodextrin complexation and solid dispersions. In addition, we highlight the factors affecting drug absorption and/or bioavailability, the methodologies available to prepare bioavailability-enhanced products, stability issues and examples of technology implementation.
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