Journal
DRUG DISCOVERY TODAY
Volume 18, Issue 1-2, Pages 87-92Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2012.08.001
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22689015, 24659217, 23116506, 23229004, 19059003]
- Ministry of Health and Welfare of Japan
- Global Center of Excellence Program of the Center of Education and Research for Advanced Genome-based Medicine
- Program for Promotion of Basic and Applied Researches for Innovations in Bio-oriented Industry
- Yakult Bio-Science Foundation
- Grants-in-Aid for Scientific Research [19059003, 22689015, 25116706, 24659217] Funding Source: KAKEN
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The intestinal enterocytes and other epithelial cells create physical barriers, including tight junctions and mucus layers. These cells also actively transport antibodies across the epithelium and simultaneously produce antimicrobial peptides and enzymes. These functions maintain intestinal homeostasis by allowing the selective absorption of nutrients and simultaneously preventing pathogenic infections. Recent evidence has revealed that both host-derived factors (e.g., cytokines) and gut environmental factors (e.g., commensal bacteria, dietary materials, and their metabolites) regulate the physical and immunological functions of the epithelium. Understanding the interactions between host cells and these environmental factors should help us to develop new strategies to prevent and treat immune diseases of the intestine.
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