Journal
DRUG DISCOVERY TODAY
Volume 18, Issue 7-8, Pages 389-398Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2012.11.003
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- CSIR, New Delhi, India
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Although a number of anti-inflammatory drugs have been discovered and developed to treat diseases associated with acute and chronic inflammation, many anti-inflammatories cause adverse side effects. The quinoline framework has emerged as a new template for the design and identification of novel anti-inflammatory agents. These agents are classified based on the number of substituents present on the quinoline ring or compounds containing a quinoline ring fused to other heterocycles. This review focuses on the discovery of various quinoline derivatives as inhibitors of cyclooxygenase (COX), phosphodiesterase 4 (PDE4) and tumour necrosis factor-alpha converting enzyme (TACE), along with transient receptor potential vanilloid 1 (TRPV1) antagonists.
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