Journal
DRUG DISCOVERY TODAY
Volume 17, Issue 9-10, Pages 486-495Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2011.11.007
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Solubility has a crucial role in the success of a drug candidate. Compounds with low solubility not only cause problems for in vitro and in vivo assays, but also add significant burdens to drug development. Drug discovery and drug development often have different solubility screening requirements and methodologies have been developed to meet the needs of these different stages.
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