Journal
DRUG DISCOVERY TODAY
Volume 17, Issue 15-16, Pages 905-912Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2012.03.015
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Evidence supporting the action of passive diffusion and carrier-mediated (CM) transport in drug bioavailability and disposition is discussed to refute the recently proposed theory that drug transport is CM-only and that new transporters will be discovered that possess transport characteristics ascribed to passive diffusion. Misconceptions and faulty speculations are addressed to provide reliable guidance on choosing appropriate tools for drug design and optimization.
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