Journal
DRUG DISCOVERY TODAY
Volume 17, Issue 13-14, Pages 665-670Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2012.01.015
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The pharmaceutical industry is in the process of re-inventing its pipeline in an attempt to overcome its increasing phase II and III attrition rates. Here, we describe how systems pharmacology can be used as a risk assessment tool to alleviate this problem before bringing in larger investments. We propose that this translational research tool could provide a valuable, complementary addition to other emerging innovative approaches for target identification and validation in discovery and, ultimately, for aiding clinical trial optimization.
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