Journal
DRUG DISCOVERY TODAY
Volume 17, Issue 1-2, Pages 35-43Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2011.09.016
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Funding
- CNRS
- INSERM
- INSERM Transfert
- la Fondation pour la Recherche Medicale
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Pancreatic cancer belongs to the group of extremely aggressive human cancers; conventional cancer treatments have little impact. Increasing understanding of the pathways associated with pancreatic cancer progression has enabled the development of targeted therapy on this cancer. Heat shock proteins (HSPs) and related heat shock response (HSR) pathways control multiple important oncogenic pathways for pancreatic cancer development. Consequently, they represent promising novel targets for pancreatic cancer therapy. Various strategies have been proposed and elaborated to target HSPs/HSR in pancreatic cancer with the corresponding modulators, the details of which are highlighted in this review.
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