Journal
DRUG DISCOVERY TODAY
Volume 16, Issue 7-8, Pages 354-360Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2010.02.009
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Funding
- National Cancer Institute [RO1 CA129011]
- MOST [2006CB933301]
- Department of Defense [W81XWH-06-1-0751]
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Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor (R) EL). In this review, several major nanonization techniques that seek to overcome these limitations for drug solubilization are presented. Strategies including drug nanocrystals, nanoemulsions and polymeric micelles are reviewed. Finally, perspectives on existing challenges and future opportunities are highlighted.
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