Journal
DRUG DISCOVERY TODAY
Volume 16, Issue 7-8, Pages 298-310Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2011.02.016
Keywords
-
Categories
Funding
- Melinda Gates Foundation [49852]
- National Institutes of Health [K08-GM074238]
Ask authors/readers for more resources
One approach to speed up drug discovery is to examine new uses for existing approved drugs, so-called 'drug repositioning' or 'drug repurposing', which has become increasingly popular in recent years. Analysis of the literature reveals many examples of US Food and Drug Administration-approved drugs that are active against multiple targets (also termed promiscuity) that can also be used to therapeutic advantage for repositioning for other neglected and rare diseases. Using proof-of-principle examples, we suggest here that with current in silico technologies and databases of the structures and biological activities of chemical compounds (drugs) and related data, as well as close integration with in vitro screening data, improved opportunities for drug repurposing will emerge for neglected or rare/orphan diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available