Journal
DRUG DISCOVERY TODAY
Volume 14, Issue 1-2, Pages 102-107Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2008.11.006
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Funding
- Div Of Industrial Innovation & Partnersh [0740943] Funding Source: National Science Foundation
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3D cell culture technologies have revolutionized our understanding of cellular behavior, both in culture and in vivo, but adoption by cell-based screening groups has been slow owing to problems of consistency, scale and cost. The evolving field of high content screening technologies will, however, require a rethinking of 3D cell culture adoption to ensure the next generation of cells provide relevant in vivo-like data. Three current technologies are presented in this review: membranes, sponges/gels and microcarriers. A short history of these technologies and unique research applications are discussed. Also, the technologies are evaluated for usefulness in modern automated cell-based screening equipment.
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